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KMID : 0861120150190010131
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Korean Journal of Oriental Preventive Medicine
2015 Volume.19 No. 1 p.131 ~ p.144
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Anti-Obesity Effect of Herbal Mixture Powder and Water Extracts in Mice Fed a High Fat Diet
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Youn Je-dong
Choi Yun-Hee
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Abstract
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Objective : This study was conducted to investigate anti-obesity effects of mixed-Powder(Raphani Semen, Coicis Semen, Poria, Plantaginis Testa & Theae folium)(HP) & mixed water extract(Citri Pericarpium, Crataegi Fructus, Maydis Stigma, Allium Skin) (HE) in mice fed a high-fat diet.
Method : 50 Female ICR mice were divided into six groups; Normal group (Ve), high-fat diet group (Po), Po+HP(0.6g/kg) group(HP), Po+HE(1g/kg) group(HE), Po+(HP+HE) group(HPE), Po+(HP+HE)*2 group(DHPE). For 8 weeks, these groups were fed their respective diets. Body weight, liver weight and weights of adipose tissues, GOT/GPT index changes & Blood Glucose index changes were measured respectively. Lipid profiles in serum were analyzed by kit of blood.
Results : Groups HP, HE, HPE, DHPE had significantly reduced body weight, liver weight, adipose tissue weights and GOT/GPT index, blood glucose index compared to the Po group. Also, serum triglyceride and total cholesterol, low density lipoprotein, were significantly reduced when compared to the Po group. Group G1 had significantly increased high density lipoprotein levels.
Conclusion : Mixed powder (HP) & mixed water extract (HE) show anti-obesity effects in mice fed a highfat diet.
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KEYWORD
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anti-obesity, herbal mixture powder, herbal mixture extracts, high-fat diet
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